Essential SAFeEssential SAFe is most basic configuration of the framework and it provides the minimal elements necessary to be successful with SAFe.
Large Solution SAFeLarge Solution SAFe is for enterprises that are building large and complex solutions, which do not require the constructs of the portfolio level.
Portfolio SAFePortfolio SAFe provides portfolio strategy and investment funding, Agile portfolio operations, and Lean governance.
Full SAFeFull SAFe represents the most comprehensive configuration. It supports building large, integrated solutions that typically require hundreds of people or more to develop and maintain.

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What’s New in SAFe 4.6?
SAFe 4.6 is an incremental improvement to the a-Framework that provides guidance on the five core competencies that help an organization become a Lean Enterprise. We have also provided new guidance for applying SAFe in a government context. Moreover, SAFe 4.6 is fully backward compatible with SAFe 4.5, allowing for a smooth migration.